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-Aminothiazoles+iodine+ ketones; NEt+ thiazoles

A Simple and Efficient Method for the Synthesis of -Aminothiazoles Under Mild Conditions

NEt3 was found to be a simple, mild, and efficient catalyst for the synthesis
of 2-aminothiazole derivatives from the reaction of different ketones,
thiourea, and iodine in EtOH media under mild conditions for the first
time. Present methodology offers several advantages, such as simple
procedure, shorter reaction times, and milder conditions, and takes
place at reflux temperature, with operational simplicity and with excellent
yields.


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