In this research, an efficient method for the one-pot synthesis of
2-aminothiazoles via the reaction of thiourea with methylcarbonyls in
the presence of iodine as an oxidant reagent has been developed
using asparagine as a green organocatalyst at 80 C in DMSO solvent.
Advantages of this efficient method include greener and cleaner
conditions, easy isolation of products, higher purity and excellent yield of
products, and convenient manipulation.